120 research outputs found
Saturation Spectroscopy of Iodine in Hollow-core Optical Fibre
We present high-resolution spectroscopy of Iodine vapour that is loaded and
trapped within the core of a hollow-core photonic crystal fibre (HC-PCF). We
compare the observed spectroscopic features to those seen in a conventional
iodine cell and show that the saturation characteristics differ significantly.
Despite the confined geometry it was still possible to obtain sub-Doppler
features with a spectral width of ~6 MHz with very high contrast. We provide a
simple theory which closely reproduces all the key observations of the
experiment.Comment: 12 pages, 7 figure
Optimized coupling of cold atoms into a fiber using a blue-detuned hollow-beam funnel
We theoretically investigate the process of coupling cold atoms into the core
of a hollow-core photonic-crystal optical fiber using a blue-detuned
Laguerre-Gaussian beam. In contrast to the use of a red-detuned Gaussian beam
to couple the atoms, the blue-detuned hollow-beam can confine cold atoms to the
darkest regions of the beam thereby minimizing shifts in the internal states
and making the guide highly robust to heating effects. This single optical beam
is used as both a funnel and guide to maximize the number of atoms into the
fiber. In the proposed experiment, Rb atoms are loaded into a magneto-optical
trap (MOT) above a vertically-oriented optical fiber. We observe a
gravito-optical trapping effect for atoms with high orbital momentum around the
trap axis, which prevents atoms from coupling to the fiber: these atoms lack
the kinetic energy to escape the potential and are thus trapped in the laser
funnel indefinitely. We find that by reducing the dipolar force to the point at
which the trapping effect just vanishes, it is possible to optimize the
coupling of atoms into the fiber. Our simulations predict that by using a
low-power (2.5 mW) and far-detuned (300 GHz) Laguerre-Gaussian beam with a
20-{\mu}m radius core hollow-fiber it is possible to couple 11% of the atoms
from a MOT 9 mm away from the fiber. When MOT is positioned further away,
coupling efficiencies over 50% can be achieved with larger core fibers.Comment: 11 pages, 12 figures, 1 tabl
Laser frequency comb techniques for precise astronomical spectroscopy
Precise astronomical spectroscopic analyses routinely assume that individual
pixels in charge-coupled devices (CCDs) have uniform sensitivity to photons.
Intra-pixel sensitivity (IPS) variations may already cause small systematic
errors in, for example, studies of extra-solar planets via stellar radial
velocities and cosmological variability in fundamental constants via quasar
spectroscopy, but future experiments requiring velocity precisions approaching
~1 cm/s will be more strongly affected. Laser frequency combs have been shown
to provide highly precise wavelength calibration for astronomical
spectrographs, but here we show that they can also be used to measure IPS
variations in astronomical CCDs in situ. We successfully tested a laser
frequency comb system on the Ultra-High Resolution Facility spectrograph at the
Anglo-Australian Telescope. By modelling the 2-dimensional comb signal recorded
in a single CCD exposure, we find that the average IPS deviates by <8 per cent
if it is assumed to vary symmetrically about the pixel centre. We also
demonstrate that series of comb exposures with absolutely known offsets between
them can yield tighter constraints on symmetric IPS variations from ~100
pixels. We discuss measurement of asymmetric IPS variations and absolute
wavelength calibration of astronomical spectrographs and CCDs using frequency
combs.Comment: 11 pages, 7 figures. Accepted for publication in MNRA
Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke
There is currently only one clinically approved drug, tissue plasminogen activator (tPA), for the treatment of acute ischaemic stroke. The RhoA pathway, including RhoA and its downstream effector Rho kinase (ROCK), has been identified as a possible therapeutic target. Our aim was to assess the impact of study design characteristics and study quality on reported measures of efficacy and to assess for the presence and impact of publication bias. We conducted a systematic review and meta-analysis on publications describing the efficacy of RhoA and ROCK inhibitors in animal models of focal cerebral ischaemia where outcome was assessed as a change in lesion size or neurobehavioural score, or both. We identified 25 published papers which met our inclusion criteria. RhoA and ROCK inhibitors reduced lesion size by 37.3% in models of focal cerebral ischaemia (95% CI, 28.6% to 46.0%, 41 comparisons), and reduced neurobehavioural data by 40.5% (33.4% to 47.7%, 30 comparisons). Overall study quality was low (median=4, interquartile range 3-5) and measures to reduce bias were seldom reported. Publication bias was prevalent and associated with a substantial overstatement of efficacy for lesion size. RhoA and ROCK inhibitors appear to be effective in animal models of stroke. However the low quality score, publication bias and limited number of studies are areas which need attention prior to conducting clinical trials
Added Value Measures in Education Show Genetic as Well as Environmental Influence
Does achievement independent of ability or previous attainment provide a purer measure of the added value of school? In a study of 4000 pairs of 12-year-old twins in the UK, we measured achievement with year-long teacher assessments as well as tests. Raw achievement shows moderate heritability (about 50%) and modest shared environmental influences (25%). Unexpectedly, we show that for indices of the added value of school, genetic influences remain moderate (around 50%), and the shared (school) environment is less important (about 12%). The pervasiveness of genetic influence in how and how much children learn is compatible with an active view of learning in which children create their own educational experiences in part on the basis of their genetic propensities
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
Publication bias confounds attempts to use systematic reviews to assess the efficacy of various interventions tested in experiments modelling acute ischaemic stroke, leading to a 30% overstatement of efficacy of interventions tested in animals
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